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Improving Health and Reducing Premature Mortality in People with Severe Mental Illness (R01)

Grants to USA Non-Profits & Others to Research
Health Interventions for the Mentally Ill

Agency Type:


Funding Source:

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National Institutes of Health

LOI Date:


Deadline Date:

11/07/13 5 PM local time of applicant organization.


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Grants are available to USA and territories non-profits, businesses, universities, and others for research aimed at reducing premature mortality of individuals with serious mental illness. Eligible organizations can receive funds to research interventions that will decrease the health risk factors that contribute to premature mortality among adults with serious mental illness or to research common modifiable health risk factors at an early stage in the developmental process as it relates to children and youth with serious emotional disturbances.

This initiative will support research that builds on strategies proven effective in reducing modifiable health risk factors in the general population. Applications that develop and test service interventions for large-scale delivery of these effective strategies to people with severe mental illness (SMI) or serious emotional disturbances (SED) are encouraged. To that end, critical aspects of the intervention and delivery strategy should be designed so as to support broad dissemination and implementation of the approach should it prove effective. The research generated should address at least one of the following questions:

1. How can strategies proven effective for reducing common modifiable health risk factors in the general population be adapted with the goal of achieving equivalent effectiveness for people with SMI or SED?
2. How can capacity to deliver needed health risk prevention and reduction be significantly improved to reach the largest number of people with SMI or SED?

In addition, NIMH encourages applicants to also consider factors influencing implementation of the services intervention that is the focus of the research project. Services interventions with health promotion, lifestyle change and self-management components for people with SMI are encouraged, as well as those integrating intervention components in order to target multiple health risk factors and/or increase the magnitude of treatment effects. Examples of services interventions for people with SMI or SED might include, but are not limited to, those involving one or more of the following:

* Diabetes prevention
* Cardiovascular disease prevention
* Obesity prevention
* Fitness and diet improvement
* Psychotropic polypharmacy reduction
* Tobacco cessation
* Antipsychotic medication management that maximizes optimal psychiatric and functional outcomes while minimizing side effects and adverse health consequences

The services intervention must specifically target people with SMI or SED and modifiable health risk factors that are the primary causes of premature mortality in this population. Ideally, the services intervention will have the following features:

* Demonstrated clinical effectiveness of the intervention's core components in the general population (although adaption may be needed for equivalent effectiveness in people with SMI or SED);

* Relevance to the life circumstances of people with SMI or SED;

* Conducted in a community-based setting that serves as a platform to engage this population (either within or outside of traditional healthcare settings);

* Potential to produce clinically (not just statistically) significant health improvement and reduction in common modifiable health risk factors associated with early mortality in people with SMI;

* Target all people with SMI or SED in a given setting, community or care delivery system;

* High likelihood for real-world feasibility in terms of required resources, staffing, training, and patient acceptability;

* Strong potential to be expanded easily to many settings, so as to reach a large portion of people with SMI or SED at risk, should the services intervention prove clinically effective with this population.

GrantWatch ID#:

GrantWatch ID#: 133399

Estimated Total Program Funding:


Number of Grants:

5 - 8

Estimated Size of Grant:

Up to $499,999/year

Term of Contract:

Up to 5 years.


  • Alaska Native and Native Hawaiian Serving Institutions
  • City or township governments
  • Community-based Organizations; CBO(s)
  • County governments
  • Eligible Agencies of the Federal Government
  • Faith-based Organizations
  • For profit organizations other than small businesses
  • Hispanic-serving Institutions
  • Historically Black Colleges and Universities; HBCU
  • Independent school districts
  • Indian/Native American Tribal Governments (Other than Federally Recognized)
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Regional Organizations
  • See RFP and/or Grant Guidelines for full eligibility
  • Small businesses
  • Special district governments
  • State governments
  • Tribally Controlled Colleges and Universities (TCCUs).

Additional Eligibility Criteria:

U.S. Territory or Possession
Asian American Native American Pacific Islander Serving Institutions (AANAPISISs)

Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.

Pre-Application Information:

Letter of Intent Due Date: October 7, 2013. Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.

Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

Applicant organizations must complete and maintain the following registrations which must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible.

(1) Dun and Bradstreet Universal Numbering System (DUNS) - All registrations require that applicants be issued a DUNS number. After obtaining a DUNS number, applicants can begin both SAM and eRA Commons registrations. The same DUNS number must be used for all registrations, as well as on the grant application.

(2) System for Award Management (SAM) (formerly CCR) – Applicants must complete and maintain an active registration, which requires renewal at least annually. The renewal process may require as much time as the initial registration.

(3) eRA Commons - Applicants must have an active DUNS number and SAM registration in order to complete the eRA Commons registration. Organizations can register with the eRA Commons as they are working through their SAM or registration. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.

(4) – Applicants must have an active DUNS number and SAM registration in order to complete the registration.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

eRA Commons Help Desk (Questions regarding eRA Commons registration, submitting and tracking an application, documenting system problems that threaten submission by the due date, post submission issues):
Phone: 301-402-7469 or 866-504-9552 (Toll Free)

Web ticketing system:
TTY: 301-451-5939
Email: Customer Support (Questions regarding registration and submission, downloading forms and application packages)
Contact Center Phone: 800-518-4726

GrantsInfo (Questions regarding application instructions and process, finding NIH grant resources)
Telephone 301-435-0714
TTY 301-451-5936

Susan T. Azrin, Ph.D.
National Institute of Mental Health (NIMH)
Telephone: 301-443-3267

Peer Review:
David Armstrong
National Institute of Mental Health (NIMH)
Telephone: 301-443-3534

Financial/Grants Management:
Tamara Kees
National Institute of Mental Health (NIMH)
Telephone: 301-443-8811

CFDA Number:


Funding or Pin Number:


URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

International country outside of the USA, Israel and Canada.

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