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Maternal Serum Screening

Grants to North Carolina Medical Centers
to Identify High Risk Pregnancies

Agency Type:


Funding Source:

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North Carolina Department of Health and Human Services - Division of Public Health

LOI Date:


Deadline Date:

01/17/14 5 PM


Request a Grant Writer

Grants are available to North Carolina medical centers with genetics programs and an operational maternal serum screening lab to provide screening for doctors seeking to detect high risk pregnancies. Grantees will provide maternal serum screening and interpretation, educate doctors, and interpret lab results. Grantees must also provide maternal screening services to indigent women living in a specific region of the state and/or across the entire state.

The selected applicants will provide direct services on a per specimen cost basis that addresses the following two outcomes: (1) to increase access to maternal serum screening for pregnant women with low income or who are medically under-served in the state and (2) to reduce neonatal mortality and the incidence of chronic handicapping conditions.

Screening Services -Maternal Serum Screening (MSS):

1. Receive MSS samples for testing of AFP, hCG, uE3, and inhA (MSAFP/quad screen) from physicians in NC providing prenatal care for pregnant women with low income.

2. Conduct lab tests at contractor facility five days a week according to current practice standards, including those established by the College of American Pathologists.

3. Provide second trimester prenatal screening for major fetal malformations by the Quad Screen using the serum markers for the following:
· Maternal serum alpha-feto protein (MSAFP)
· Maternal serum human chorionic gonadatrophin (hCG)
· Maternal serum unconjugated estriol (uE3)
· Inhibin A (inhA).

4. Interpret test results for health care providers.

5. Report test results to referring health care provider(s) within one week after receipt of specimen in the laboratory.

6. Provide physicians, health care providers or health departments (as indicated on laboratory request form) a written report of all results. For abnormal results or those requiring interpretations or further action, notify by telephone or FAX on the same day the result becomes available.

7. Provide literature, telephone and email consultations to physicians regarding various genetic conditions associated with maternal serum screening in the service area as requested.

8. Communicate with the physician/health-care provider as requested regarding interpretation of results and proper management guidelines in an effort to assure the best health care for the patient and her pregnancy.

9. Annually provide continuing and new education regarding MSAFP/hCG/UE3/inh-A screening along with the following "support materials" to physicians and health departments in the following service areas:
· Educational materials (protocol and instructions for screening, patient brochures)
· Lab slips
· Mailing containers
· Information about new developments in maternal serum screening, diagnosis, treatment and follow-up.

Other Services:

1. Provide technical assistance to local providers submitting samples to assure that Medicaid/presumptive eligibility cards or insurance cards accompany all samples.

2. Maintain comprehensive patient records which must be available for audit as needed to further document the monthly financial reports.

GrantWatch ID#:

GrantWatch ID#: 138960

Estimated Total Program Funding:


Number of Grants:


Estimated Size of Grant:


Term of Contract:

The contract(s) developed may be renewed annually for a maximum of two years.

Additional Eligibility Criteria:

Public or private non-profit medical centers with a genetics program and a fully functioning AFP laboratory.

Pre-Application Information:

Any agency that plans to submit an application shall submit a Notice of Intent no later than 5pm on 12/20/2013 to Lara Percenti.

Written questions concerning the specifications in this Request for Applications will be due by 5PM on 1/2/2014. As an addendum to this RFA, a summary of all questions and answers will be released on 1/7/2014 to all agencies and organizations sent a copy of this Request for Applications.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Lara Percenti

Funding or Pin Number:


URL for Full Text (RFP):

Geographic Focus:

USA: North Carolina