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2014-2015 Proof of Concept Grants

Grants to Washington For-Profits & Non-Profits for
Life Sciences Research & Development Projects

Agency Type:

Foundation / Corporation

Funding Source:

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Life Sciences Discovery Fund

LOI Date:


Deadline Date:

03/04/15 5:00 PM


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Large grants to Washington for-profit and non-profit organizations that are seeking financial assistance to support life sciences research and development and/or commercialization-related initiatives. The next pre-proposal submission deadline is January 7, 2015. The goal of these grants is to improve human health and health care, stimulate economic activity, create and retain jobs, and promote life sciences competitiveness in Washington.

The expected outcome of a Proof of Concept grant depends on the applicant organization:
- If the applicant is a non-profit entity: to markedly enhance the probability that promising new technologies and concepts will be transitioned from the university and non-profit environments and be developed into products.
- If the applicant is a for-profit entity: help position early-stage Washington life sciences companies with commercially promising health-related technologies for their first significant round of equity investment funding.

Proof of Concept grants support research and development activities focused on demonstrating proof of principle or constructing prototypes. Types of projects envisioned include, but are not limited to, the following:
- Experiments to validate a technology’s use for a generic purpose: that a novel method can be used to deliver a chemical substance; or that a new assay reporter system has an acceptable sensitivity range.
- Experiments to validate a technology’s use for a specific purpose: an animal study to show that inhibition of an enzyme has a desired clinical effect; confirmation that a specific biomarker correlates with disease; or measurement of a physiological parameter in an animal model in response to treatment with a therapeutic device.
- Construction of a prototype product: assembly of an integrated research instrument to facilitate use with human subjects; chemical modification of a promising compound to generate a more suitable candidate drug; or development of a graphical user interface for a piece of software.
- Testing of a prototype: use of an instrument to image a specific anatomical region; pharmacokinetic studies on a possible drug lead; testing that a software tutorial can improve clinical practice; or safety or efficacy trials of a new drug or device in human subjects.

Expenditures to advance the business case for the proposed product (e.g., support of an entrepreneur-in-residence at a non-profit organization, or regulatory consultation) are allowable provided that they also advance the scientific/technical plan.

GrantWatch ID#:

GrantWatch ID#: 148759

Estimated Total Program Funding:


Estimated Size of Grant:

The maximum award is $250,000 in total costs.

Additional Eligibility Criteria:

Eligible non-profit applicant organizations are Washington state governmental or non-profit entities that have recently engaged in competitively funded, sponsored research, or similar activities, and have the personnel, resources, and experience necessary to accomplish work of the type described within this RFP.

Eligible for-profit applicants and their proposed work must meet all the following criteria, either as an organization or in their application:

- Resources to conduct the work: having or engaging the personnel, resources, and expertise necessary to accomplish the proposed activities.

- Substantial presence in Washington, which is determined by LSDF based on factors including, but not limited to: number of full-time equivalent employees who are residents of Washington and their relative levels of compensation compared to other sites of corporate activity; having research and development, administrative, or manufacturing facilities located in Washington; payment of Washington Business and Occupation or other taxes; or any combination of such factors. For-profit applicant organizations must be registered business entities within the state of Washington. This will be verified by a corporation search via the State of Washington Business Licensing Service.

- $500,000 or less in equity investment: For-profit applicant organizations must not have raised more than $500,000 in equity financing, including convertible debt. This is consistent with LSDF’s desire to support start-up entities.

- Intellectual property access: Applicants must have clear access, such as a license or outright ownership, to the technology that is the focus of the application by the time of award execution.

Pre-proposal Conference:

Pre-Application Information:

All applicants must submit a pre-proposal through LSDF’s online system to be considered for a grant. Only a subset of pre-proposals will be invited to submit a proposal. Click here to access the online application system:

Key dates for the upcoming grant cycle are as follows:
Pre-Proposal Submission: January 7, 2015
Notification of Invite/Not Invite Status: February 3, 2015
Proposal Submission: March 4, 2015

Please Note: Pre-proposal interviews have been eliminated, as has the limit on the number of pre-proposals accepted per cycle.

To access further application instructions and information, see the right side of the URL for Full Text (RFP) for a complete list of documents to download.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.


URL for Full Text (RFP):

Geographic Focus:

USA: Washington

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