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Grants to USA Businesses, Non-Profits, Others for Trials to Reduce Hypertension Among At-Risk Populations


Intent to Apply Date


Application Deadline

02/13/15 5:00 PM Local time of applicant

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CFDA or PIN Number:

CFDA Number:

93.837, 93.853

Funding or PIN Number:



Geographic Focus

USA: AlabamaAlaskaArizonaArkansasCaliforniaColoradoConnecticutDelawareFloridaGeorgiaHawaiiIdahoIllinoisIndianaIowaKansasKentuckyLouisianaMaineMarylandMassachusettsMichiganMinnesotaMississippiMissouriMontanaNebraskaNevadaNew HampshireNew JerseyNew MexicoNew York CityNew YorkNorth CarolinaNorth DakotaOhioOklahomaOregonPennsylvaniaRhode IslandSouth CarolinaSouth DakotaTennesseeTexasUtahVermontVirginiaWashington, DCWashingtonWest VirginiaWisconsinWyoming

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Testing Multi-Level Interventions to Improve Blood Pressure Control in Minority Racial/Ethnic, Low Socioeconomic Status, and/or Rural Populations (UH2/UH3)

National Institute of Health, Department of Health and Human Services, Patient-Centered Outcomes Research Institute (PCORI)

Agency: Federal

GrantWatch ID #149609

Grant Description

Grants to USA government agencies, businesses, non-profits, universities, and others for clinical trials designed to reduce high blood pressure among at-risk populations. January 13, 2015 is the deadline for the optional letter of intent. Awardees will evaluate various evidence based methods of blood pressure control among disproportionately affected populations such as racial and ethnic minorities, individuals with low socioeconomic status, and rural communities.

For the purposes of this FOA, high risk populations are those with an elevated risk of fatal and non-fatal cardiovascular disease outcomes and for whom it has been challenging to achieve a high rate (>75%) of blood pressure control. Many high risk populations are served in health care facilities such as Federally Qualified Health Centers (FQHCs), and community clinics. Many of these populations include a significant proportion of patients insured through Medicaid.

Planning, implementation, recruitment, retention, and dissemination, and other aspects of the trials will involve patients and key stakeholders in meaningful ways to assure the trial success.

Research Strategy: The project's overall goals are to improve clinical practice and lead to improvement in blood pressure control and other related patient-centered outcomes in disparities populations. Trials must be based on comparative study designs and must not include cost-effectiveness analyses. The overall active intervention strategy should be based on a comprehensive model of the remedial causes of disparities in hypertension among these high risk populations and the health care system in which these trials will occur.

Projects must be for patient-centered, comparative effectiveness research that specifically targets disparities in hypertension management. To avoid duplication, encourage innovation, and enhance utility of future research findings, the proposed trials must be innovative and different from previous and ongoing research by the proposing research team and past trials by other investigators.

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  • Alaska Native and Native Hawaiian Serving Institutions
  • City or township governments
  • Community-based Organizations; CBO(s)
  • County governments
  • Eligible Agencies of the Federal Government
  • Faith-based Organizations
  • For profit organizations other than small businesses
  • Historically Black Colleges and Universities; HBCU
  • Independent school districts
  • Indian housing authorities
  • Indian/Native American Tribal Governments (Other than Federally Recognized)
  • Institutions of Higher Education; IHE(s)
  • Native American tribal governments (Federally recognized)
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • Public and State controlled institutions of higher education
  • Public housing authorities/Indian housing authorities
  • Regional Organizations
  • Others (see text field entitled "Additional Eligibility Criteria" for clarification)
  • Small businesses
  • Special district governments
  • Tribally Controlled Colleges and Universities (TCCUs).
  • U.S. Territory or Possession
  • State Agencies

Additional Eligibility Criteria:

Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)

Pre-Application Information:

January 13, 2015: Deadline for letter of intent. Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.

See also:

Applicant organizations may submit more than one application, provided that each application is scientifically distinct.

The NIH will not accept duplicate or highly overlapping applications under review at the same time. This means that the NIH will not accept:

* A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.

* A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.

* An application that has substantial overlap with another application pending appeal of initial peer review (see NOT-OD-11-101).

In addition, the NIH will not accept a resubmission (A1) application that is submitted later than 37 months after submission of the new (A0) application that it follows. The NIH will accept submission:
* To an RFA of an application that was submitted previously as an investigator-initiated application but not paid;
* Of an investigator-initiated application that was originally submitted to an RFA but not paid; or
* Of an application with a changed grant activity code.

Additional Funding Information:

Number of Grants:

Up to 4.

Estimated Size of Grant:

The UH2 Phase is limited to $650,000 direct costs for a one year period. The UH3 Phase is limited to $1,800,000 direct costs for each subsequent year (2 to 5).

Term of Contract:

The anticipated start date for the project is September 2015. The UH2 phase will be one year in length and the UH3 phase may be up to 4 years.

Contact Information:

eRA Commons Help Desk (Questions regarding eRA Commons registration, submitting and tracking an application, documenting system problems that threaten submission by the due date, post submission issues)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)
Finding Help Online:
Email: Customer Support (Questions regarding registration and submission, downloading forms and application packages)
Contact Center Telephone: 800-518-4726
Web ticketing system:

Grants Info (Questions regarding application instructions and process, finding NIH grant resources)
Telephone: 301-435-0714
Scientific/Research Contact(s)

Lawrence J. Fine, MD DrPH
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-0305

Salina Waddy, MD
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-496-9135

Peer Review Contact(s):
Director, Office of Scientific Review
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-0270

Financial/Grants Management Contact(s):

Tawana McKeither
National Heart, Lung, and Blood Institute (NHLBI)
Telephone: 301-435-0166

Tijuanna DeCoster, PhD
National Institute of Neurological Disorders and Stroke (NINDS)
Telephone: 301-496-9231

The letter of intent should be sent to:

Director, Office of Scientific Review
National Heart, Lung, and Blood Institute
6701 Rockledge Drive, Room 7214
Bethesda, MD 20892-7924 (Express Mail Zip: 20817)

Telephone: 301-435-0270

RFP & Supporting Documents:

Full Grant Text RFP

Before starting your grant application, please review the funding source's website listed below for updates / changes / addendums / conferences / LOIs.

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