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2021 Million Dollar Bike Ride (MDBR) Pilot Grant Program

Grants to USA, Canada, and International
Researchers for Research on Rare Diseases

Agency Type:

Foundation / Corporation

Funding Source:

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University of Pennsylvania School of Medicine - Orphan Disease Center (ODC)

LOI Date:


Deadline Date:

10/18/21 8:00 PM EST


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Grants to USA, Canada, and International faculty-level academic researchers and senior scientific researchers at nonprofit institutions for medical research related to rare diseases. Applicants must submit a letter of inquiry prior to submitting a full proposal. Funding is intended to support research related to a rare disease represented in the 2021 Million Dollar Bike Ride.

Research Areas for the 2021 MDBR Grant Program:

  1. Adult Polyglucosan Body Disease (APBD)
  2. Ataxia-Telangiectasia (A-T)
  3. BPAN- A Neurodegeneration with Brain Iron Accumulation Disorder
  5. Castleman Disease
  6. CDKL5 Deficiency Disorder
  7. Choroideremia (CHM)
  8. Complex Lymphatic Anomalies (CLA)
  9. Congenital Hyperinsulinism (CHI)
  10. Congenital Muscular Dystrophy (CMD)
  11. Cohen Syndrome (COH)
  12. Nonsense Mutations in Cystic Fibrosis
  13. Dyskeratosis Congenita & Telomere Biology Disorder
  14. Fibrous Dysplasia/McCune Albright Syndrome
  15. Fibrodysplasia Ossificans Progressiva (FOP)
  16. Glut1 Deficiency Sundrome
  17. Lymphangioleiomyomatosis (LAM)
  18. Mucopolysaccharidoses (MPS)
  19. MPS Gene Spotlight: Mucopolysaccharidosis (MPS I)
  20. Maple Syrup Urine Disease (MSUD)
  21. Mitochondrial Complex 1 Deficiency Disorder - NUBPL
  22. Mucolipidosis Type IV (ML4)
  23. Neuroendocrine cell Hyperplasia of Infancy (NEHI)
  24. Niemann Pick Type C (NPC)
  25. Pitt Hopkins Syndrome (PTHS)
  26. RASopathies
  27. SETBP1 Disorder
  28. Snyder-Robinson Syndrome (SRS)
  29. STXBP1 Encephalopathy
  30. TBCK Syndrome

Allowable direct costs:

  • Salary for PI
  • Salary/stipend and related benefits for graduate student/postdoctoral fellow/technical support
  • Travel (up to $1,500)
  • Laboratory supplies and other research expenses
  • IDCs of 10% are included in the total award amount

More information about Research Focus Areas for Pilot Grants can be found at

GrantWatch ID#:

GrantWatch ID#: 160999

Number of Grants:

The number of grants depends on the research area. See page 2 of the RFA in Supporting Documents below for a list of total grants.

Estimated Size of Grant:

The total budget depends on the research area. See page 2 of the RFA in Supporting Documents below for a list of total funds.

Term of Contract:

This is a one year grant.

Additional Eligibility Criteria:

All individuals holding a faculty‚Äźlevel appointment at an academic institution or a senior scientific position at a non-profit institution or foundation are eligible to respond to this RFA.

Unallowable costs:
- Consultation costs
- Tuition
- Professional membership dues
- Equipment >$5,000
- General office supplies, institutional administrative charges (e.g. telephone, other electronic communication, IT network, - etc. )
- Pre-award charges
- Any other expenses not directly related to the project

Pre-Application Information:

LOI Due Date: Thursday, September 16, 2021 no later than 8pm (EST)

NOTE: Full Application is by invitation only after review of Pre-Application

Proposal Due Date: Monday, October 18, 2021 no later than 8pm (EST) Full application documents are to be uploaded on the website, by invitation only.

Funds will be issued through a cost reimbursement mechanism executed by purchase order from the University of Pennsylvania.

Million Dollar Bikeride:

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Submit LOI online:

For any administrative inquiries regarding this grant please email Samantha Charleston at

University of Pennsylvania
TRL Suite 1200
125 South 31st Street
Philadelphia, PA 19104

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;


International country outside of the USA, Israel and Canada.

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