Foundation / Corporation
Pancreatic Cancer Action Network and Celgene Corporation
12/21/18 Noon EST
Grants to USA, Canada, and International biomedical scientists affiliated with a qualifying research, medical, or academic institution for high priority research on pancreatic cancer. This grant will support research that is poised for crucial translational next steps that will apply scientific discovery to real-world application in patients. Proposed research should aim to identify novel targets and approaches to the treatment of pancreatic cancer or understand and circumvent treatment resistance.
The Pancreatic Cancer Action Network has partnered with the Celgene Corporation to accelerate the development of novel therapies by establishing strong relationships between academia and industry through research grants. Funded projects will benefit from industry input and insight, leading to an accelerated translation into a therapeutic product. Projects will be strategically supported by both the Pancreatic Cancer Action Network and Celgene to facilitate progress and increase the likelihood of success.
To be eligible for a Translational Research Grant, the research project should aim to identify novel targets and approaches to the treatment of pancreatic cancer or understand and circumvent treatment resistance. Of particular interest are research projects that fall into at least one of these three areas of research: a) Immune context and tumor microenvironment interactions, (b) Regulators of pathogenesis, progression and metabolism, with particular interest in epigenetic mechanisms and (c) Transcriptional networks essential for viability and maintenance of malignant phenotype.
Study Scope and Project Topics:
Projects should be built on a strong foundation of basic research and propose steps that translate that finding into a drug or immunologic approach to the treatment of pancreatic cancer. The intent of the project should be to extensively validate novel targets and/or identify novel approaches to the treatment of pancreatic cancer or understand and circumvent treatment resistance. Translational research involving robust animal models is permitted but there is emphasis on the incorporation of human tumors or tumor-derived tissue. There is particular interest in co-development of a biomarker that can be used to identify a subset of pancreatic cancer patients most likely to respond to the proposed therapeutic intervention. Projects should not include proprietary compounds for which the PI or institution does not control intellectual property rights. It is recognized that translation into clinical testing is unlikely to be feasible within the scope of these projects.
Application projects are limited to the following:
1. The study of a molecular treatment or approach but not a device or surgical intervention.
2. A molecular treatment or approach that is novel and within the intellectual property rights of the applicant's institution. Combination treatments that are dependent on proprietary compounds outside the control of the applicant are not permitted.
3. Studies that fall into at least one of these three areas of interest:
- Immune context and tumor microenvironment interactions.
- Regulators of pathogenesis, progression and metabolism, with particular interest in epigenetic mechanisms.
- Transcriptional networks essential for viability and maintenance of malignant phenotype.
The following are examples of projects that fall within the project scope of the 2019 Translational Research Grant. Please note that these are examples and projects are not restricted to these specific projects.
-In-depth studies to understand the impact of disrupting a molecular mechanism that regulates a component of the immune response (e.g., T-cell exclusion) in a genetically-engineered mouse model of pancreatic cancer with supporting data from human pathological specimens.
-Molecular mechanisms underlying the role of factors produced by supporting cells, such as macrophages, myeloid-derived suppressor cells and/or fibroblasts, in paracrine support of tumor epithelial cell proliferation using complex modeling systems (e.g., human tumor-derived cells in organotypic models).
-Studies to understand short and long term effects of disrupting the activity of a chromatin remodeling enzyme or a Zn-finger transcription factor on tumor cell proliferation and metabolism in molecularly characterized patient-derived xenografts (or other complex model systems).
-Studies in murine or human tumors testing the impact of disrupting transcriptional nodes identified by previous bioinformatics.
Use of Funds:
Funds can be used for salaries and benefits, laboratory supplies, equipment (maximum of 10 percent of total grant), subject trial costs and publication charges for manuscripts that pertain directly to the proposed project. Expenses for regular communications can be included if a co-PI is located at a different institution.
For institutions that mandate payment of indirect costs, a maximum of 10 percent of the total grant may be used for this purpose across all institutions.
Please be advised that the Celgene Corporation will be involved with the funded project, will have access to project results such as progress reports and will have first negotiation rights for further project development. Further, publishable manuscripts that result from funded projects are subject to editorial review by Celgene. If the applicant believes that this creates a conflict or for further information, please contact the Foundation before applying.
GrantWatch ID#: 166433
It is anticipated that four Translational Research Grants will be awarded.
The Translational Research Grant provides $500,000 over two years.
If expanded for a third year, an additional $250,000 will be granted.
The project term is two years; however, contingent on success, projects may be expanded to a third year. Expansion will be determined separately from this application. The grant term begins July 1, 2019.
Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.
Apply online through proposalCENTRAL:
Inquiries or technical issues regarding proposalCENTRAL and the online application process should be directed to customer support at:
Toll-free: (800) 875-2562
Inquiries about the 2019 Translational Research Grant guidelines and application materials should be directed to the Pancreatic Cancer Action Network at:
Maya Bader, PhD, Scientific Grants Manager
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