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Investigators in the Pathogenesis of Infectious Disease (PATH) Program

Grants to USA and Canada Researchers for Studies Related
to the Development of Communicable Diseases

Agency Type:

Foundation / Corporation

Funding Source:

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Burroughs Wellcome Fund (BWF)

LOI Date:


Deadline Date:

11/15/21 12:00 PM Eastern Time


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Grants to USA and Canada researchers affiliated with a nonprofit IHE to study the development of communicable diseases. Applicants must submit a pre-proposal prior to submitting a full proposal. Funding is intended for researchers at the assistant professor level to explore the interaction between humans and microorganisms. The goal of the program is to provide opportunities for investigators, who are accomplished yet still at an early stage in their careers, to study how humans and potentially infectious agents are affected by their encounters.

The Investigators in the Pathogenesis of Infectious Disease program provides opportunities for assistant professors to bring multidisciplinary approaches to the study of human infectious diseases. The goal of the program is to provide opportunities for accomplished investigators still early in their careers to study what happens at the points where the systems of humans and potentially infectious agents connect. The program supports research that sheds light on the fundamentals that affect the outcomes of these encounters: How colonization, infection, commensalism, and other relationships play out at levels ranging from molecular interactions to systemic ones.

PATH provides funding to support investigators at the assistant professor level to study pathogenesis, with a focus on the interplay between infectious agents and their hosts, shedding light on how both are affected by their encounters. The awards are intended to give recipients the freedom and flexibility to pursue new avenues of inquiry, stimulating higher-risk research projects that hold potential for significantly advancing understanding of how infectious diseases work and how health is maintained.

Important Notes:

  • Microbiome-related proposals must be infectious disease focused to compete well in this program.
  • BWF encourages submissions from those working in protozoan and metazoan parasites, protists, and fungi. Viral, bacterial, immune, and multi-species work is likewise encouraged. Work related to malaria, tuberculosis, and AIDs is appropriate for this program. BWF particularly encourages human health-relevant applications from veterinary scientists.
  • BWF encourages submissions focusing on climate change and its impact on the pathogenosis of infectious disease and human health.

The support allocated for research is under the control of the awardee and may be used flexibly for items such as equipment, consumable supplies, travel to scientific meetings, and salaries for laboratory personnel working with the awardee.

GrantWatch ID#:

GrantWatch ID#: 171502

Estimated Size of Grant:

PATH provides $500,000 to support investigators.

Term of Contract:

PATH provides funds over a period of five years:
- Award start date July 1, 2022
- Award end date June 30, 2027

Additional Eligibility Criteria:

The ideal candidate is an accomplished investigator at the mid-to-late assistant professor level with an established record of independent research in a tenure-track position or its well-supported equivalent in non-tenure offering departments.

Applications must be approved and signed by an official responsible for sponsored programs (generally from the grants office, office of research, or office of sponsored programs) at a degree-granting institution. Candidates will generally have a Ph.D. and/or a clinical doctorate (M.D., D.V.M., etc.).
- Candidates must have an established record of independent research.
- Citizens and non-citizen permanent and temporary residents of the U.S. and Canada who are legally qualified to work in the U.S. or Canada are eligible. Candidates who are temporary U.S. residents must hold a valid U.S. visa (J-1, H1B, F-1 or O-1 visas). Temporary Canadian residents must hold a valid Canadian visa (Study Permit, C-43, C44, C-10, or C-20 work permits/visas).
- Candidates who will be promoted to Associate Professor by November 15, 2021 are not eligible to apply.
- Candidates who have completed a Burroughs Wellcome Fund career development award (CAMS or CASI) are encouraged to apply but must contact BWF before writing the pre-proposal. Having had BWF travel, career guidance for trainees, preterm birth, regulatory science, or PDEP grants does not impact PATH support.

Important Notes:
- The PATH award can only be made to accredited, degree-granting institutions in the U.S. or Canada. An Internal Revenue Service determination letter of the institution’s non-profit status may be requested by BWF staff if one is not on file in the office.
- BWF strongly encourages applications from women and underrepresented minorities.

The PATH award may not be used to pay student tuition.

Pre-Application Information:

Key Dates:
- Pre-proposal applications due: July 16, 2021, 12:00 pm Eastern Time. Pre-proposals will not be accepted after this date and time.
- Invitation to submit a full proposal: October 1, 2021, 12:00 pm Eastern Time
- Full proposal due: November 15, 2021, 12:00 pm Eastern Time
- Finalist interviews: April 26-27, 2022
- Notice of award: May 20, 2022
- Award start date: July 1, 2022
- Award end date: June 30, 2027

Only pre-proposals submitted through BWF’s online application website IGAM will be accepted.

Applying for this award is a two-stage process:
1. Pre-proposals. Interested candidates who meet the eligibility criteria may submit one online pre-proposal through BWF’s Internet Grant Application Module (IGAM).
2. Full proposals. Submission of full proposals will be by invitation only after review of pre-proposals. By October 1, 2021, those who make it to the next round will be invited to submit a full research proposal. Instructions on how to prepare a full research proposal will be provided by email with the invitation to participate.

Prior approval by BWF is required when, within an award year, purchases of equipment exceed $20,000 or travel costs exceed $8,000.

PATH is a career development award made to a degree-granting institution on behalf of an awardee. Institutions are responsible for disbursing the funds and for maintaining adequate supporting records and receipts of expenditures.

About the PATH Award:

Pre-Proposal Forms and Resources:


Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Online portal:

Eligibility inquiries should be directed in advance to BWF program staff by contacting:

Victoria McGovern, Ph.D., Senior Program Officer

Muno Sekhon, Program Associate, 919-991-5122

Burroughs Wellcome Fund
21 T.W. Alexander Drive
PO Box 13901
Research Triangle Park, NC 27709-3901
(919) 991-5100

URL for Full Text (RFP):

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USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;

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