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ADDF-Harrington Scholar Program

Grants to USA MDs and PhDs for Research Related to the Development
of Drugs to Cure, Treat, and Prevent Alzheimer's Disease

Agency Type:

Foundation / Corporation

Funding Source:

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Harrington Discovery Institute and Alzheimer’s Drug Discovery Foundation (ADDF)

LOI Date:

04/12/19

Deadline Date:

07/19/19

Description:

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Grants to USA scientists with MD and PhD degrees for research into the development of drugs to cure, treat, and prevent Alzheimer's disease. Applicants must submit a Letter of Intent prior to submission of a full application. Funding is intended to provide drug development support and to help bridge the gap between basic discovery and the clinical realm.

The ADDF-Harrington Scholar Award selection committee seeks breakthrough discovery defined by innovation, creativity and potential clinical impact, including:
- Discoveries deemed to address unmet medical needs
- Modulators of novel targets
- Potential to be developed into a commercial program
- Possess strong intellectual property (IP) or protection strategy
- May be either a small molecule, biologic, or other therapeutic modality
- Diagnostics or devices only acceptable as part of a therapeutic development project or if completely transformative.

The Harrington Discovery Institute and its Innovation Support Center team will work closely with the awardee and their affiliated institution to maximize the clinical and commercial potential of the selected project. In addition to funding, the award includes:
- Drug development expertise and project management support through the Harrington Discovery Institute Innovation Support Center
- Consulting services from highly experienced drug development personnel
- Business and commercialization advice
- Clinical development advice
- Regulatory assistance
- Intellectual property review and advice
- Assistance identifying and securing additional financial support based on project needs.

Projects will be assessed based on:
- Quality of the science and the scientist
- Novelty and innovative quality of the work
- Potential for impact on human health.

Use of Funds:
- General: No more than $10,000 of the total grant can be used for capital expenditures or equipment. The award may only be used for direct project expenses, not for institutional overhead.
- Salary: The award may be used to cover salaries for post-docs equivalent to the percentage of effort devoted to the project. Please note that PI’s salary is limited to 10% of the total award amount.


GrantWatch ID#:

GrantWatch ID#: 182103

Number of Grants:

Up to three ADDF-Harrington Scholar awards are made each year through a competitive selection process.

Estimated Size of Grant:

Funding up to $600,000

Term of Contract:

Two years.

Additional Eligibility Criteria:

To be eligible for the award, an applicant must meet the following requirements:
- Hold an MD or MD/PhD (or equivalent)
- Hold a faculty position at an accredited academic medical center, university or research institution in the US, and conduct the majority of his/her research activities at that institution
- Proposals should support the development of small molecule or biologic to treat, prevent or slow Alzheimer’s disease, other dementias and cognitive aging
- A project may have only a single PI, who is responsible for project oversight and financial management. The PI may engage collaborators, core labs or commercial CROs to execute any fraction of the project.
- Past recipients of Harrington Scholar-Innovator awards may submit new and distinct proposals, but may not seek additional support for previously funded projects.

Investigators may apply from accredited academic medical centers, research institutions or universities in the U.S., and U.S. territories. Institutions must provide the necessary facilities and infrastructure for the research, and accept the conditions of the award, including the Budget & Use of Funds. They must assure compliance with the prevailing national guidelines for animal and human studies, and provide proper oversight of the Grant funds.

Sponsoring institutions must safeguard the rights and welfare of individuals who participate as subjects in research activities by reviewing proposed activities through an Institutional Review Board (IRB) as specified by the U.S. Department of Health and Human Services Office for Human Research Protections, HHS OHRP. Additionally, the Grantee’s institution must assure appropriate governance of animal studies. IRB approval and IACUC numbers are not required at the time of application, but must be provided for final signature of the Grant Agreement, which will be sent to Grantees shortly after they have been selected.

Additionally, sponsoring institutions must adhere to current US Department of Health and Human Services guidelines regarding financial conflict of interest, recombinant DNA and research misconduct.

The award may not be used for travel, meetings, professional fees, publication fees, etc.

Pre-Application Information:

Key Dates:
- Call for Letters of Intent Opens: February 15, 2019
- Letter of Intent Submission Deadline: April 12, 2019
- Full Proposal Deadline (for those invited): July 19, 2019
- Awards announced: November 2019

The Harrington Scientific Symposium, held in late spring in Cleveland, Ohio, will bring together drug development experts, national disease foundation leadership, and international leaders in medicine and Harrington Scholars. Awardees are expected to present their project and findings-to-date. A stipend for travel and lodging will be provided by Harrington Discovery Institute, subject to the terms of the Award Agreement.

Additional information: https://www.uhhospitals.org/harrington-discovery-institute/funding-and-programs/alzheimers-drug-discovery-foundation-harrington-program/award-program-details

Policies :https://www.uhhospitals.org/harrington-discovery-institute/funding-and-programs/alzheimers-drug-discovery-foundation-harrington-program/policies

How to Apply: https://www.uhhospitals.org/harrington-discovery-institute/funding-and-programs/alzheimers-drug-discovery-foundation-harrington-program/how-to-apply

Funding Opportunities: https://www.alzdiscovery.org/research-and-grants/funding-opportunities

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Apply online: https://addf.fluxx.io/

Any questions should be directed to HDIQuestions@HarringtonDiscovery.org.

Alzheimer's Drug Discovery Foundation
57 West 57th Street, Suite 904
New York, NY 10019
info@alzdiscovery.org
212.901.8000

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming