National Institutes of Health (NIH) - National Institute of Allergy and Infectious Diseases (NIAID)
07/02/20 5:00 PM Local Time
Grants to USA, Canada, and International nonprofit organizations, IHEs, schools, government agencies, and for-profits for scientific research to develop vaccines. Applicants are advised that required registrations may take several weeks to complete. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications to support the development of promising universal influenza vaccine candidates that protect against both influenza A and B viruses. For this RFA, the NIAID is only accepting applications that do not propose clinical trials.
NIAID’s Strategic Plan for the Development of a Universal Influenza Vaccine provides a research agenda for understanding and addressing scientific challenges to overcome suboptimal vaccine effectiveness and support activities focused on development of a universal influenza vaccine. Universal influenza vaccines would provide markedly improved breadth and durability of protection compared to currently licensed products. Emphasis is placed on development of a vaccine against IAV to address the combined seasonal and pandemic threats caused by IAV subtypes. However, there is significant interest in the development of vaccines that can provide broad, durable protection against both IAV and IBV strains, thus further optimizing preventive measures against seasonal influenza.
Research Objectives and Scope
The objective of this Funding Opportunity Announcement (FOA) is to support milestone-driven research projects focused on establishing proof-of-concept for and/or preclinical development of candidate universal influenza vaccines that protect against IBV or both IAV and IBV. Of particular interest are projects that include the development and/or characterization of IBV vaccine components that complement existing lead IAV vaccine candidates. It also is anticipated that this initiative will stimulate innovative, potentially high-risk approaches that support the discovery and early development of novel universal influenza vaccine candidates. The R21 phase of the award may include proof-of-concept studies and/or lead candidate optimization. For the purpose of this FOA, universal influenza vaccines are defined as providing improved breadth and/or durability of protection compared to licensed, quadrivalent seasonal influenza vaccines. “Candidate vaccine” is defined as a vaccine or related vaccine product and may include, but is not limited to, novel approaches in nucleic acid vaccination; new/improved replicating or non-replicating recombinant vectors; new/improved live attenuated vaccine virus; and/or nanoparticle design that demonstrate enhanced humoral and cell-mediated responses across multiple IAV and IBV strains. “Lead candidate” is defined as a candidate vaccine for which proof-of-concept data have been obtained and “preclinical development” is defined as all activities beyond lead candidate identification.
Examples of potential research efforts to be supported may include, but are not limited to:
GrantWatch ID#: 189171
Application budgets are limited to $275,000 in direct costs over the two-year project period for the R21 phase, with a maximum of $200,000 in direct costs allowed in any single year. The R33 award phase is limited to $300,000 in direct costs per year.
Earliest Start Date: March 2021
This FOA will use the R21/R33 Phased Innovation award mechanism. Support will be provided for two years for the R21 phase (for milestone-driven exploratory or feasibility studies) and up to three years of support may follow for the R33 phase (for expanded development).
Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.
Apply online using ASSIST: https://public.era.nih.gov/assist
eRA Commons login: https://public.era.nih.gov/commons/public/login.do?TARGET=https%3A%2F%2Fpublic.era.nih.gov%2Fcommons%2FcommonsInit.do
Application Submission Contacts
eRA Service Desk (Questions regarding ASSIST, eRA Commons, application errors and warnings, documenting system problems that threatensubmission by the due date, and post-submission issues)
Finding Help Online:http://grants.nih.gov/support/(preferred method of contact)
Telephone: 301-402-7469 or 866-504-9552 (Toll Free)
General Grants Information (Questions regarding application instructions, application processes, and NIH grant resources)
Email:GrantsInfo@nih.gov(preferred method of contact)
Grants.gov Customer Support(Questions regarding Grants.gov registration and Workspace)
Contact Center Telephone: 800-518-4726
Michael Schaefer, Ph.D.
National Institute of Allergy and Infectious Diseases (NIAID)
Peer Review Contact(s)
Jian Wang, M.D, Ph.D.
Center for Scientific Review (CSR)
Financial/Grants Management Contact(s)
National Institute of Allergy and Infectious Diseases (NIAID)
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