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CDMRP PRMRP Investigator-Initiated Research Award for Emerging Viral Diseases and Respiratory Health

Assistance Agreements to USA, Canada, and International
Organizations for Research Related to the Novel Coronavirus

Agency Type:

Federal

Funding Source:

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U.S. Department of Defense (DoD) - U.S. Army Medical Research Acquisition Activity (USAMRAA)

LOI Date:

05/28/20

Deadline Date:

06/12/20 11:59 PM ET

Description:

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Assistance agreements to USA, Canada, and International organizations for health research related to the novel Coronavirus (COVID-19), specifically in the areas of emerging viral diseases and respiratory health. Applicants must submit an LOI prior to submitting a full application.

The vision of the FY20 PRMRP is to improve the health, care, and well-being of all military Service members, Veterans, and beneficiaries, and its mission is to encourage, identify, select, and manage medical research projects of clear scientific merit and direct relevance to military health. Thus, the proposed research must be relevant to active duty Service members, Veterans, military beneficiaries, and/or the American public. The PRMRP challenges the scientific and clinical communities to address at least one of the FY20 PRMRP Topic Areas of Emerging Viral Diseases and Respiratory Health with original ideas that foster new directions along the entire spectrum of research and clinical care. 

The FY20 PRMRP Focus Areas for Emerging Viral Diseases and Respiratory Health are listed below.

Emerging Viral Diseases 

  • On-demand identification, isolation, characterization, and manufacturing of antibodies (monoclonal or polyclonal) from peripheral blood mononuclear cells (PBMCs) collected from patients with coronavirus disease 2019 (COVID-19). 
  • Development of a wearable sensor that provides real-time diagnostics that can be used as a point of care for emerging viral diseases to predict illness before the onset of symptoms. The diagnostic platform should be applicable to COVID-19. Virus-specific markers that can identify viruses at the genus level can be included, with an emphasis on SARS-CoV-2, the virus that causes COVID-19. 
  • Surveillance and predictive modeling tools that leverage artificial intelligence approaches to predict outbreaks and epidemics and support strategies for mitigating the threat of COVID-19.
  • Triage of care for COVID-19 patients requiring access to resource-intensive interventions. 
  • Research to understand novel molecular and biological mechanisms of COVID-19 health impacts (e.g., microbiome) and identification/validation of biochemical, physiological, or combined biomarkers for evaluating short- and long-term health impacts from COVID-19. 
  • Research to determine direct and indirect impacts of COVID-19 on military readiness and unit climate; interpersonal/family dynamics; behavioral and mental health issues such as depression, suicide, anxiety, and loneliness, and other key risk factors such as substance abuse and risky health-related behaviors. The aim of such research should be to inform, develop, and test potential behavioral countermeasures (e.g., knowledge and information products, preparedness training, support resources, self-care, and team-care recommendations) to mitigate negative impacts and maximize Service member and family readiness/resilience to stressors related to pandemics and disasters. 

Respiratory Health 

  • Research on the etiology and prevention of acute respiratory distress syndrome (ARDS) caused by host responses to coronaviruses, particularly COVID-19. 
  • Development of improved methods for assessing and treating lung injury due to coronaviruses, particularly COVID-19. 
  • Novel and/or innovative detection technologies or therapeutics to reduce the incidence and/or severity of ARDS and/or other lung injury secondary to coronaviruses, particularly COVID-19.
  •  Development of biomarker metrics to associate the long-term health outcomes of virus-induced ARDS with degradation of physiological and physical performance. 
  • Ventilation and Extracorporeal Life Support approaches and technologies to support lung function or airway management in response to COVID-19 that increase survivability and/or minimize care provider burden or exposure. 
  • Pharmacological and biologic interventions for COVID-19 induced complications, including ARDS and related sequelae. 
  • Research on the short- and long-term health impacts of COVID-19 diagnosed Service members on readiness, deployability, fitness for duty (e.g., ability to complete the Army Combat Fitness Test), and operationally relevant respiratory challenges such as challenges in fixed-wing aviation, diving, and high-altitude ground operations.  
  • Research on the prevention of COVID-19 (and other respiratory pathogens) in aircraft, ships, and submarines, specifically focused on ventilation systems and ease of transport of airborne pathogens (i.e., risk characterizations).

For more information on research impact and research projects, see https://cdmrp.army.mil/funding/pa/FY20-PRMRP-IIRA-COV.pdf#page=5.

Partnering Principal Investigator (PI) Option: As a method to facilitate progress in addressing critical problems or questions through collaborative efforts, the FY20 PRMRP is offering a Partnering PI Option for this award mechanism. For more information, see https://cdmrp.army.mil/funding/pa/FY20-PRMRP-IIRA-COV.pdf#page=5.

GrantWatch ID#:

GrantWatch ID#: 189617

Estimated Total Program Funding:

$12,000,000

Number of Grants:

The CDMRP expects to fund approximately four Investigator-Initiated Research Award applications for Emerging Viral Diseases and/or Respiratory Health.

Term of Contract:

Funds to be obligated on any award resulting from this funding opportunity will be available for use for a limited time period based on the fiscal year of the funds. It is anticipated that awards made from this FY20 funding opportunity will be funded with FY20 funds, which will expire for use on September 30, 2026.

The maximum period of performance is 4 years.

Additional Eligibility Criteria:

All organizations, including international organizations, are eligible to apply.

Government Agencies Within the United States: Local, state, and Federal Government agencies are eligible to the extent that applications do not overlap with their fully funded internal programs. Such agencies are required to explain how their applications do not overlap with their internal programs.

As applications for this Program Announcement may be submitted by extramural and intramural organizations, these terms are defined below.
- Extramural Organization: An eligible non-DoD organization. Examples of extramural organizations include academic institutions, biotechnology companies, foundations, Federal Government organization other than the DoD, and research institutes.
- Intramural DoD Organization: A DoD laboratory, DoD military treatment facility, and/or DoD activity embedded within a civilian medical center. Intramural Submission: Application submitted by a DoD organization for an intramural investigator working within a DoD laboratory or military treatment facility or in a DoD activity embedded within a civilian medical center..

Principal Investigator: Investigators at or above the level of Assistant Professor (or equivalent) may be named by the organization as the PI on the application. Partnering PI Option: Investigators at or above the level of Assistant Professor (or equivalent) that bring complementary skills and perspectives to the research project.

An eligible PI, regardless of ethnicity, nationality, or citizenship status, must be employed by, or affiliated with, an eligible organization.

USAMRAA makes awards to eligible organizations, not to individuals.

This award may not be used to conduct clinical trials. The cost of preparing applications in response to a Program Announcement is not considered an allowable direct charge to any resultant award.

Submission of applications that are essentially identical or propose essentially the same research project to different funding opportunities within the FY20 PRMRP is prohibited and will result in administrative withdrawal of the duplicative application(s). As an exception, applicants may submit the research project described in their Investigator-Initiated Research Award application as part of an application to the FY20 PRMRP Focused Program Award (Funding Opportunity Number: W81XWH-20-PRMRP-FPA); however, accepting multiple awards to support the same project will not be allowed.

Pre-Application Information:

Submission and Review Dates and Times
• Pre-Application Submission Deadline: 5:00 p.m. Eastern time (ET), May 28, 2020
• Application Submission Deadline: 11:59 p.m. ET, June 12, 2020
• End of Application Verification Period: 5:00 p.m. ET, June 16, 2020
• Peer Review: July 2020
• Programmatic Review: August 2020
• Awards will be made no later than September 30, 2021.

Application submission is a two-step process:
Step 1. Pre-application submission.
Step 2. Full application submission: Full applications must be submitted through the online portals as described below.

Full Application Submission Guidelines:
- Extramural Application Submissions: Full applications from extramural organizations must be submitted through Grants.gov Workspace. To apply through Grants.gov, an organization must first complete the Grants.gov registration process. Allow up to 8 weeks for the completion of the Grants.gov registration process. Registering early is advised.
- Intramural Application Submissions: Intramural DoD organizations may submit full applications to either eBRAP or Grants.gov.
Note: Applications from an intramural DoD organization or from an extramural Federal Government organization may be submitted to Grants.gov through a research foundation.

Applicants are required to be registered as follows:
1. DUNS - For more information see https://cdmrp.army.mil/funding/pa/FY20-PRMRP-GAI.pdf#page=8 and https://cdmrp.army.mil/funding/pa/FY20-PRMRP-GAI.pdf.
2. SAM - For more information see https://cdmrp.army.mil/funding/pa/FY20-PRMRP-GAI.pdf#page=8 and https://www.sam.gov.
3. CAGE - For more information, see https://cdmrp.army.mil/funding/pa/FY20-PRMRP-GAI.pdf#page=9 and https://cage.dla.mil/Request
4. Each organization must have an AOR who is registered with Grants.gov (individual PIs do not register with Grants.gov).

Partnering PI Option: The CDMRP requires separate full application package submissions for the Initiating PI and the Partnering PI, even if the PIs are located within the same organization. If recommended for funding, each PI’s organization will receive their own separate award.

For information about expenses incurred before the beginning date of the initial budget period of a new award, see https://cdmrp.army.mil/funding/pa/FY20-PRMRP-GAI.pdf#page=17.

View this opportunity on Grants.gov at: https://www.grants.gov/web/grants/view-opportunity.html?oppId=326174

eBRAP FAQs: https://ebrap.org/eBRAP/public/FAQ.htm

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

All pre-applications for both extramural and intramural organizations must be submitted through eBRAP: https://ebrap.org/

Questions related to Program Announcement content or submission requirements as well as questions related to the pre-application or intramural application submission through eBRAP should be directed to the CDMRP Help Desk:
Phone: 301-682-5507
Email: help@eBRAP.org

Questions related to extramural application submission through Grants.gov portal should be directed to the Grants.gov Contact Center:
Phone: 800-518-4726; International 1-606-545-5035
Email: support@grants.gov

CFDA Number:

12.420

Funding or Pin Number:

W81XWH-20-PRMRP-IIRA-COV

URL for Full Text (RFP):

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Israel

International country outside of the USA, Israel and Canada.

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