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Accelerating Drug Discovery for Frontotemporal Degeneration

Grants to USA, Canada, and International Academic Medical Centers, IHEs,
Nonprofits, and Biotechnology Companies for Drug Development Programs

Agency Type:

Foundation / Corporation

Funding Source:

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Alzheimer’s Drug Discovery Foundation (ADDF) and Association for Frontotemporal Degeneration (AFTD)

LOI Date:


Deadline Date:

07/30/21 5:00 PM ET


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Grants to USA, Canada, and International academic medical centers and universities, nonprofit organizations, and biotechnology companies for drug development programs. Applicants must submit a letter of intent prior to submitting a full proposal. Funding is intended to support innovative small molecule and biologic drug development programs for frontotemporal dementia (FTD). Drug targets in the areas of inflammation and proteostasis will be considered high priority.

There are currently no FDA approved disease-modifying treatments available for frontotemporal dementia (FTD) and symptomatic treatments only provide limited benefit for patients. Recent scientific advances have provided an increased understanding of pathogenic mechanisms underlying FTD and are driving the development of potential disease-modifying therapies. The Alzheimer’s Drug Discovery Foundation (ADDF) and The Association for Frontotemporal Degeneration (AFTD) seek to accelerate this progress by supporting innovative small molecule and biologic (antibodies, oligonucleotides, peptides, gene therapy etc.) drug development programs for FTD through this request for proposals (RFP).
The RFP supports:
  • Lead optimization of novel disease-modifying compounds, including medicinal chemistry refinement and in vitro ADME.
  • In vivo testing of novel lead compounds, biologics, vaccines, or repurposed drug candidates in relevant animal models for pharmacokinetics, dose-range finding, target engagement, in vivo efficacy, and/or preliminary rodent tolerability studies.
Current target areas of interest include, but are not limited to:
  • Inflammation
  • Proteostasis
  • Autophagy
  • Epigenetics
  • Genetic Causes of Disease (C9ORF72, MAPT, GRN, etc.)
  • Misfolded proteins (TDP-43, tau, FUS etc.)
  • Mitochondria & Metabolic Function
  • Neuroprotection
  • Synaptic Activity & Neurotransmitters
The ADDF's mission is to accelerate discovery of a novel treatment for Alzheimer's disease and other related dementias. The ADDF seeks to fulfill its mission by providing funding for drug discovery and development projects. As a public charity, the ADDF’s funding must be used specifically for an approved scientific project that advances the ADDF's stated mission.
ADDF funding may be provided for approved personnel costs, supplies (e.g., consumables, chemicals, animals), small non-durable equipment up to $2,500, consultants, and patient costs related to clinical trials.

GrantWatch ID#:

GrantWatch ID#: 191063

Estimated Size of Grant:

$100,000 - $150,000 based on stage and scope of research.

Term of Contract:

Average Duration: One year with potential for follow-on funding.

Additional Eligibility Criteria:

Funding is open to researchers and clinicians in the U.S. and worldwide working in:
- Academic medical centers and universities or nonprofits. Industry partnerships are encouraged.
- Biotechnology companies that demonstrate a clear need for nonprofit funding. Funding is provided through mission-related investments (MRIs) that require return on investment based upon scientific and/or business milestones. Existing companies and new spinouts are both eligible.

This RFP does not support target identification, target validation, assay development, high-throughput and high-content screening. IND-enabling work is supported through ADDF’s PACT RFP.

ADDF funding is not provided for indirect costs/overhead, capital equipment, equipment service contracts, publication costs, or travel (unless travel is pre-approved under special circumstances).

Pre-Application Information:

- Letter of Intent: May 28th, 2021
- Invited Full Proposal: July 30th, 2021

Applications must be received by 5:00 pm ET on the deadline date.

Log in or create an account using the ADDF Funding Portal to begin the application process. Please note, new applicants should allow 1-2 business days for registration.

Applications are reviewed in a two-step process:
1. Letters of Intent (LOI): ADDF’s science team will evaluate LOIs to determine whether the proposed project is consistent with the ADDF's mission and funding priorities. Generally, applicants can expect to be notified within 2-3 weeks of their LOI submission.
2. Invited full proposal: Invited full proposals are reviewed by members of the external scientific and business review boards. Generally, applicants can expect to be notified within 3-4 months of their full proposal submission.

Applicants unable to submit the full proposal by the deadline may submit their proposal during the next cycle without submitting a new LOI, unless the proposed work has changed. After two missed deadlines, applicants must submit a new LOI.

Applicants may only submit one LOI per cycle and one invited full proposal per cycle, but a single academic institution may have multiple applicants apply for funding for different projects within a cycle. Biotechnology companies are limited to the submission of one LOI and one invited full proposal per cycle.

ADDF-funded investigators that wish to apply for follow-on funding are encouraged to contact ADDF scientific staff three months prior to the end of the funding period.

Application instructions:

Funding policies:

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Online application portal:

For program-related inquiries, please contact:

Debra Niehoff, PhD, Scientific Director, AFTD

Alessio Travaglia, PhD, Assistant Director, Scientific Affairs, ADDF

For application submission inquiries, please contact:
Grants and Mission-Related Investments Team

Alzheimer's Drug Discovery Foundation
57 West 57th Street, Suite 904
New York, NY 10019

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;


International country outside of the USA, Israel and Canada.

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