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Grant to a USA Nonprofit or IHE for Research that
Fosters Collaboration Between Mathematics and Biology

NSF-Simons Collaboration on a National Institute for Theory and Mathematics in Biology (NITMB)

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Foundation / Corporation

Funding Source:

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National Science Foundation Directorates for Mathematical and Physical Sciences (NSF/MPS) and for Biological Sciences (NSF/BIO) and Simons Foundation Division of Mathematics and Physical Sciences (SF/MPS)

LOI Date:


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Grant to a USA nonprofit organization or IHE for research that fosters collaboration between mathematics and biology. Applicants must submit an LOI prior to submitting a full application. Required registrations may take several weeks to complete. The purpose of the program is to support innovative research projects that advance knowledge of both scientific fields.

This solicitation responds directly to the need to facilitate long-term collaborations between the biological and the mathematical sciences communities to leverage their complementary expertise, and to build capacity to address important basic research and societal challenges whose solutions are best solved by expertise at the intersection of disciplines.

The NSF-Simons Collaboration on a National Institute for Theory and Mathematics in Biology is a large-scale project that should have several important impacts, including:

  • Advance research at the interface of mathematical and biological sciences by enabling impactful collaborations between mathematical scientists and biologists to reveal new insights of important and fundamental biological problems through developments of new mathematical theories, novel modeling and statistical approaches, as well as innovative computational methodologies;
  • Foster research that is timely and potentially transformative, and assist rapid and broad dissemination of new ideas at the interface of mathematical and biological research;
  • Increase and expand the talent base, with special attention to increasing diversity, equity, inclusion, and accessibility engaged in research at the interface of mathematical and biological sciences;
  • Provide opportunities for students and postdoctoral fellows to interact with leading researchers in inclusive environments;
  • Demonstrate leadership in promoting diversity in the mathematical and biological sciences;
  • Provide opportunities for outreach to the scientific community and the public at large;
  • Support the exchange of information with business, industry, government, and national laboratories, providing access to expertise in the mathematical and biological sciences;
  • Play an important role in fostering international collaborations in mathematical and biological sciences.

The National Science Foundation and the Simons Foundation invite proposals for projects that contribute to this important, influential institute partnership activity.

For more information, see the following link:

GrantWatch ID#:

GrantWatch ID#: 199159

Estimated Total Program Funding:


Number of Grants:


Estimated Size of Grant:

The Simons Foundation estimates that $25,000,000 will be available to support the institute award over the five-year duration of the award.

Term of Contract:

NSF and the Simons Foundation have each committed funding to support one institute over five years, with an anticipated extension for another five-year period at the same funding level.

Additional Eligibility Criteria:

Proposals may only be submitted by the following:
- Institutions of Higher Education (IHEs) - Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members. Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education (including through use of subawards and consultant arrangements), the proposer must explain the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus.
- Non-profit, non-academic organizations: Independent museums, observatories, research labs, professional societies and similar organizations in the U.S. associated with educational or research activities.

Pre-Application Information:

- Preliminary Proposal Deadline (by 5 p.m. submitter's local time): December 1, 2021
- Full Proposal Target Date(s): July 18, 2022

Preliminary Proposals (required): Preliminary proposals are required and must be submitted via the NSF FastLane system, even if full proposals will be submitted via

Before using for the first time, each organization must register to create an institutional profile. Once registered, the applicant's organization can then apply for any federal grant on the website. Comprehensive information about using is available on the Applicant Resources webpage:

Notification of the award is made to the submitting organization by a Grants Officer in the Division of Grants and Agreements.

Program Solicitation:

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Zhilan J. Feng, National Science Foundation, telephone: (703) 292-7523, email:

Jaroslaw Majewski, National Science Foundation, telephone: (703) 292-7278, email:

Sridhar Raghavachari, National Science Foundation, telephone: (703) 292-4845, email:

Elizabeth Roy, Simons Foundation, telephone: (212) 524-6966, email:

Samuel M. Scheiner, National Science Foundation, telephone: (703) 292-7175, email:

Junping Wang, National Science Foundation, telephone: (703) 292-4488, email:

For questions related to the use of FastLane or, contact:
FastLane and Help Desk: 1-800-673-6188
FastLane Help Desk e-mail: Help Desk e-mail:

For questions relating to contact: Contact Center: If the Authorized Organizational Representatives (AOR) has not received a confirmation message from within 48 hours of submission of application, please contact via telephone: 1-800-518-4726; e-mail:

Funding or Pin Number:

NSF 21-607

URL for Full Text (RFP):

Geographic Focus:

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