Find Nonprofit and Small Business Grants

Advance Search

Only Available for Paid Subscribers
Clear Filters
Search Filters

Opportunity for California Nonprofits, For-Profits, and Social Enterprises to Participate in a Program to Advance the Health of the Underserved


Geographic Focus

USA: California: San Diego and Imperial counties

GrantRegions Object ( [regions] => Array ( ) [is_initialized] => [error_messages] => Array ( ) [qm] => QueryManager Object ( [is_debug] => [conn] => mysqli Object ( [affected_rows] => 0 [client_info] => mysqlnd 5.0.12-dev - 20150407 - $Id: 3591daad22de08524295e1bd073aceeff11e6579 $ [client_version] => 50012 [connect_errno] => 0 [connect_error] => [errno] => 0 [error] => [error_list] => Array ( ) [field_count] => 2 [host_info] => via TCP/IP [info] => [insert_id] => 0 [server_info] => 5.5.5-10.5.18-MariaDB [server_version] => 100518 [stat] => Uptime: 3323786 Threads: 256 Questions: 562049813 Slow queries: 1318 Opens: 126072 Open tables: 2259 Queries per second avg: 169.099 [sqlstate] => 00000 [protocol_version] => 10 [thread_id] => 91900019 [warning_count] => 0 ) ) [has_regions] => 1 [state_names] => Array ( [0] => California: San Diego and Imperial counties; ) [province_names] => Array ( ) [country_names] => Array ( ) [is_israel] => [territories] => Array ( ) [free_associations] => Array ( ) )

i2 Innovation Initiative

Alliance Healthcare Foundation

Agency: Foundation

GrantWatch ID #124605

Grant Description

Opportunity for California nonprofit organizations, for-profits, and social enterprises to participate in an initiative that promotes the advancement of the health and wellness of marginalized communities in eligible locations. Participants in the program will take part in a business development workshop and have the opportunity to work with a mentor, receive technical assistance and coaching, and receive funding. The project must initially benefit the most vulnerable populations in San Diego and/or Imperial County.

With the i2 Challenge Grant, Alliance Healthcare Foundation seeks promising innovation to transform the current health paradigm of high cost and poor outcomes to improve quality, increase capacity, and reduce costs for the most vulnerable populations in San Diego and/or Imperial counties. The i2 Challenge Grant represents a 12-month demonstration and workshop cycle that allows eligible i2 applicants to hone their business plan and grant proposal with the aid of experts provided by Alliance and its Innovation Partners. The 12-months also allows the Program and Evaluation Committees time to get to know the finalists and develop a deeper understanding of their innovation solution.

i2 is a milestone-based challenge grant which includes a 12-month mentorship journey culminating in a final pitch session to a panel of judges. ACF's overarching goal is to support the winner of the i2 Challenge Grant as they go on to secure additional funding; scale their solution for maximum benefit for their focus population, and become self-sustainable.

ACF is seeking sustainable market-based innovations and/or systems-change transformations aimed at closing gaps in health equity and wellness, which have been dramatically exacerbated by the COVID-19 pandemic.

Examples of Closing Gaps (purely for illustration; not an exhaustive list): 

  • Chronic condition prevention and/or management (diabetes, obesity, cardiovascular)
  • Access to health and wellness for those without broadband connectivity, transportation, health literacy, language fluency
  • Opportunity for wealth building at lowest income levels
  • Access to mental and behavioral health care for the under- and uninsured

Eligible proposals must address one of the following:

  • Systemic Problems in the healthcare system, such as:
    • Expanding access to quality healthcare resources to all (i.e., navigation, care coordination, cultural competency or removing barriers such as transportation, health literacy, language fluency, remote monitoring, telehealth)
    • Elimination of bias within health systems (i.e., integrated care, fair financing, incorporating social determinants of health, cultural competency, language accessibility)
  • Wholistic Chronic Condition Prevention & Management, such as:
    • Leveraging technology to improve outcomes; reduce re-admission; improve adherence, etc.
    • Eliminating environmental hazards that exasperate health disparities
    • Improving access to quality and effective behavioral health services

Need help writing this grant?


  • Others (see text field entitled "Additional Eligibility Criteria" for clarification)

Additional Eligibility Criteria:

Eligible i2 Challenge Grant lead applicants include:
- Section 501(c)(3) nonprofit organizations.
- Social Enterprises. A social enterprise can be a nonprofit, certified B Corp, or for-profit organization that advances health and wellness of those in need.
- Collaborations. Collaborations can be community based programs or initiatives that are “housed” in an academic institution; a public-private team with an established tax identification; or a public-private-nonprofit team with an established tax identification. In the case of a collaboration among entities, there needs to be a lead applicant who will be authorized to bind all participant organizations, and who will receive any applicable milestone-contingent grant funds. The Alliance Healthcare Foundation shall have no responsibility to allocate or apportion any grant monies among participant organizations or entities.

i2 is not a general operating grant or follow-on funding for an existing, well-established enterprise.

The following entities are not eligible to apply for the i2 Challenge Grant:
- Mature entities that are seeking general operating funds
- Entities without a specific focus on vulnerable or historically marginalized/under-resourced populations
- Entities that seek to profit from historically marginalized/under-resourced populations
- Entities without an operating focus in San Diego and/or Imperial counties
- Individuals
- Entities formed under the laws of a country other than the United States
- Past i2 grantees
- Entities that are developing pharmaceuticals, nutraceuticals, health food, fitness service, or medical devices requiring FDA approval unless the technology is part of an evidenced-based or novel innovation that is a well-supported approach to one of the eligibility criteria above.

Pre-Application Information:

2022 i2 applications open January 1 – 28, 2022.

12-Month Timeline:
- i2 Application Posted: Week ending Friday, January 7, 2022
- i2 Kickoff Event: Week ending Friday, January 14, 2022
- i2 Application Due: Week ending Friday, January 28, 2022
- Up to 25 Applicants Selected: Week ending Friday, February 11, 2022
- Social Enterprise Start-Up Workshop(s): Week ending Friday, February 25, 2022
- Phase 1 Presentations: Week ending Friday, April 22, 2022
- Up to 10 Semi-Finalists Selected: Week ending Friday, April 29, 2022
- Phase 2 Presentations: Week ending Friday, June 24, 2022
- Up to 5 Finalists Selected: Week ending Friday, July 1, 2022
- Final Presentation: Week ending Friday, December 16, 2022
- i2 Winner Decision Made: Week ending Friday, January 13, 2023

*NOTE: Timelines for the i2 Innovation Challenge Grant program may be adjusted with sufficient notice.

2022 i2 Applicant Journey (12-month cycle that includes 3 "phases"):
- Phase 1: Proposal & Planning (January – March)
- Phase 2: Validating (April – June)
- Phase 3: Building (July – December)
- Finalist Pitch Round

For information about the above phases, see

2022 I2 Challenge page:


Additional Funding Information:

Estimated Size of Grant:

AHF will select one i2 grantee who will be eligible to receive up to a total of $1 million in grant payments to use for developing and scaling the proposed solution.

The Grantee will receive: (a) access to Alliance Healthcare Foundation’s facility located in San Diego, CA for project meetings, space allowing and reserved ahead of time, and in accordance with current public health guidelines; (b) mentorship from experienced executives in partnership with our Innovation Partner, and (c) exposure to other funders and stakeholders.

AHF recognizes the time commitment that i2 applicants will be making to participate in the i2 Journey culminating in the final pitch in December 2022. To compensate each applicant for this time, AHF will be providing stipend funding at each formal phase of the Journey as follows:

- Phase 1 (up to 25 applicants) – $1,000
- Phase 2 (up to 10 applicants) – $5,000
- Phase 3 (up to 5 finalists) – $20,000

Contact Information:

Live Chat Chat Now