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Biomedical Discovery Research Grant (Operating Grant)

Grants to Researchers Affiliated with Canada Research Institutions
for Operating Support Related to Multiple Sclerosis Research

Agency Type:

Foundation / Corporation

Funding Source:

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Multiple Sclerosis Society of Canada (MSSC)

Deadline Date:

10/01/19 4:00 PM EDT


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Grants to individual researchers affiliated with Canada research institutions for operational expenses related to multiple sclerosis research projects. Research proposals may be submitted in the areas of clinical and population health, and biomedical research which explores the pathological, biological, and mechanistic aspects of MS.

The Discovery Research Grant (Operating Grant) program is intended to support research operations that will help to generate new scientific knowledge and applications that will improve health and quality of life of people affected by MS. Grants support investigator-initiated research proposals and there are no topic restrictions imposed, other than the required demonstration of relevance to MS. Proposed research must pertain to one or more of the streams listed below: 

1. The Biomedical Discovery Research grant supports research which uncovers the various aspects of MS, and provides fundamental knowledge about the development, progression, prevention and treatment of the disease. Studies can involve in vitro, animal, and/or human models. Topics can include:

  • Treatment and Care: Research that aims to advance treatment and care for people affected by MS (e.g., symptom management, diagnosing MS, developing new treatments and understanding their mechanisms).
  • Understand and Halt Disease Progression: Research that aims to understand the mechanisms of MS, disease progression, progressive MS, and repair (e.g., myelin biology, neurobiology, neurophysiology, immunology, neuropathology, and imaging).
  • Prevent MS: Research that aims to prevent MS (e.g. identifying risk factors and effective interventions for prevention and understanding their mechanisms). 

2. The Clinical and Population Health (CPH) Discovery Research grant supports clinical research with the goal of improving diagnosis and treatment, and improving the health and quality of life of individuals, and encompasses research on, or for the treatment of, people affected by MS; and supports population health research that aims to understand the complex, biological, social, cultural and environmental interactions that determine the health of individuals and populations. Topics can include:

  •  Treatment and Care: Research that aims to advance treatment and care for people affected by MS (e.g. symptom management, diagnosing MS, developing new treatments, mental health, wellness/self-care, rehabilitation, health services, clinical care practices, models of care, healthcare delivery/policy).
  • Enhance Well-being: Research that aims to understand how to enhance the well-being of people affected by MS within communities (e.g. understanding the social determinants of health, health economics/cost benefit analysis on interventions and support structures and systems, community-based programs, health systems research/policy).
  •  Prevent MS: Research that aims to prevent MS (e.g. identifying risk factors, effective interventions for prevention, health economic/cost benefit analysis on prevention, and defining highest risk populations).

 Grant Recipients may request funds for the following categories of expenditure: Salaries for personnel, patient costs, permanent equipment, consumable supplies and travel. For additional information regarding eligible expenditures, see

GrantWatch ID#:

GrantWatch ID#: 155614

Estimated Size of Grant:

The amount that may be requested for operating research grants is approximately $100,000 per year.

Term of Contract:

The MSSC will support Discovery Research (Operating) grants for terms of one (1) to three (3) years.

Funding Start Date: April 1, 2020

Additional Eligibility Criteria:

Institutions are the official recipients of grants made for the support of specific research by the PI (Principal Investigator). MSSC only accepts applications from Canadian post-secondary institutions and their affiliated institutions including hospitals and research institutes.

The Principal Investigator is listed as the primary applicant/contact and is responsible for overseeing the research conducted as part of the proposal. The PI must be considered eligible by his or her institution to apply for a research grant. The PI does not have to be a Canadian citizen but must be conducting research in a Canadian institution which is recognized by the Tri-Council Agencies. The PI is autonomous regarding their research activities, has a faculty appointment that allows the individual to pursue the proposed research, and is equipped to supervise trainees and publish research activities.

For additional Eligibility Criteria for Co-PI, Co-Applicant, and Collaborator, see and

For ineligible expenditures, see

Pre-Application Information:


- Competition Opens: July 31, 2019
- Application Deadline: October 1, 2019 at 4:00 PM EDT*
- Anticipated Notice of Decision: March 2020
- Funding Start Date: April 1, 2020

*In the event the deadline falls on a weekend, the deadline is the following Monday.

The PI may concurrently submit a maximum of one (1) new pilot grant application and two (2) Discovery Research Grant (Operating Grant) applications per competition. The PI can hold a maximum of two Discovery Research Grants (Operating Grant) and one pilot grant at any one time. Data and outcomes that will be derived from the pilot grant should not overlap with those from an Discovery Research Grant (Operating Grant), but the topics can be related.

Resubmitting an application that was unsuccessful in the previous submission to the MSSC Discovery Research Grant (Operating Grant) competition is permitted.

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Online application portal:

Please direct all inquiries to

Multiple Sclerosis Society of Canada Research Department
250 Dundas Street West - Suite 500
Toronto, Ontario M5T 2Z5

URL for Full Text (RFP):

Geographic Focus:

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;

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