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Neuroimaging and CSF Biomarker Program

Grants to USA, Canada, and International Researchers for
Studies Related to Dementia and Alzheimer's Disease

Agency Type:

Foundation / Corporation

Funding Source:

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Alzheimer's Drug Discovery Foundation (ADDF)

LOI Date:


Deadline Date:

12/03/21 5:00 PM ET Receipt


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Grants to USA, Canada, and International clinicians and researchers for research studies related to health and disease. Applicants must submit a Letter of Intent prior to submitting a full proposal. Funding is intended to further develop and evaluate established biomarkers for which there is a clear clinical need in Alzheimer's disease and related dementias. Priority is given to biomarkers with a defined context of use, a clear advantage over other relevant biomarkers, and a path to commercialization and/or clinical use.

Specifically, this RFP focuses on:

  • Developing novel PET ligands for clinical use
  • Supporting novel CSF biomarkers
  • Validating established MRI approaches in larger cohorts

Novel biomarkers of neuroinflammation and synaptic integrity are considered a high priority. Other target areas of interest include:

  • Neuronal loss
  • Vascular injury and blood-brain barrier integrity
  • Mitochondria and metabolic function
  • Protein misfolding/proteostasis
  • Oxidative stress
  • White matter changes
  • Other novel targets supported by compelling biological rationale and connection to disease

The ADDF has limited interest in CSF measures of amyloid and tau.

The RFP supports the advancement of neuroimaging and CSF biomarkers that can do one or more of the following:

  • Demonstrate target engagement for novel therapeutics
  • Detect signs of disease earlier and monitor progression
  • More accurately diagnose and distinguish between dementia subtypes

For more information on funding priorities, see "Funding Priorities" on the URL for Full Text below.

Modality Specific Priorities:

  • Neuroimaging:
    • Positron emission tomography (PET)
    • Magnetic resonance imaging (MRI)
    • Magnetic resonance spectroscopy (MRS)
  • Cerebrospinal fluid (CSF) biomarkers
  • Functional activity measures
  • Other novel approaches

For more information on Modality Specific Priorities, see "Modality Specific Priorities" on the URL for Full Text below.

GrantWatch ID#:

GrantWatch ID#: 181960

Estimated Size of Grant:

The average award is up to $600,000 based on stage and scope of research.

Term of Contract:

- Award duration: One year with potential for follow-on funding.
- Multi-year proposals can be considered.

Additional Eligibility Criteria:

Funding is open to researchers and clinicians worldwide at:
- Academic medical centers, and universities or nonprofits. Industry partnerships are encouraged.
- Biotechnology companies. Funding is provided through mission-related investments that require a return on investment based upon scientific and/or business milestones. Existing companies and new startups are both eligible.

ADDF funding is not provided for indirect costs/overhead, capital equipment, equipment service contracts, publication costs, or travel (unless travel is pre-approved under special circumstances).

Pre-proposal Conference:

2021 ACF | create Commissioning Program Information Session Dates and Times via Zoom

Tuesday, April 6: 6:00 – 7:00 PM Central

Friday, April 9: 6:30 – 7:30 PM Central

Thursday, April 22: 6:00 – 7:00 PM Central

Friday, April 30: 6:30 – 7:30 PM Central

Saturday, May 1: 1:00 – 2:00 PM Central

Pre-Application Information:

Due to the COVID-19 pandemic, ADDF understands there may be delays in submitting applications. It will consider an extension if delays are anticipated. Please email your scientific point person listed at the end of the RFP.

Letters of Intent and Full Proposals must be received by 5:00 PM ET on the deadline date.

Upcoming Deadlines:
- Letter of Intent: February 5, 2021
- Invited Full Proposal: April 16, 2021

- Letter of Intent: May 28, 2021
- Invited Full Proposal: July 30, 2021

- Letter of Intent: October 1, 2021
- Invited Full Proposal: December 3, 2021

Applicants are encouraged to contact program staff to discuss proposed projects and receive initial feedback.

Application instructions:

Funding Policies:

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

ADDF Funding Portal:

For scientific inquiries, please contact:
Meriel Owen, PhD, Asst. Director, Scientific Affairs

For inquiries related to contracting and the online funding portal, please contact:
Grants and Mission-Related Investments Team

Alzheimer's Drug Discovery Foundation
57 West 57th Street, Suite 904
New York, NY 10019

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;


International country outside of the USA, Israel and Canada.

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