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Grants to USA Research Entities, Agencies, IHEs, Nonprofits, and For-Profits for Research Related to Medical Decision-Making

Phased Large Awards for Comparative Effectiveness Research (PLACER)


GrantWatch ID#

Funding Source
Patient-Centered Outcomes Research Institute (PCORI)
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Geographic Focus

Important Dates
LOI Date: 05/31/23
Deadline: 08/29/23 5:00 PM ET Save

Grant Description
Grants to USA research entities, including agencies, IHEs, and nonprofit and for-profit organizations, for research studies related to medical decision-making. Applicants must submit an LOI prior to applying. Funding is intended for high-quality comparative clinical effectiveness research (CER) projects that will address critical decisions faced by patients, caregivers, clinicians, and stakeholders across the health and healthcare community and for which there is insufficient evidence.

The goal of the Phased Large Awards for Comparative Effectiveness Research (PLACER) PCORI funding announcement (PFA) is to support large-scale, high-impact randomized trials in comparative clinical effectiveness research (CER) whose risk in achieving their research aims merit an initial period of testing and refinement to determine their feasibility and viability and maximize the likelihood of full-scale trial success. The initial period of testing, termed the feasibility phase, allows robust and diverse stakeholder input and engagement to assess equipoise among study participants (such as health systems, clinicians, and patients) and thus maximize their participation in the research study. As appropriate and necessary, the feasibility phase allows for refinement of the research question, outcomes, data collection methods, and data instruments. The feasibility phase is expected to include empiric testing of recruitment and enrollment assumptions and the feasibility of study conduct to detect and address unanticipated challenges to study execution before a full-scale study is implemented. Statistical rigor and power are likewise strengthened by using the feasibility phase to work collaboratively with the expertise of a Data Coordinating Center (DCC) to refine and finalize the final study size, design, and statistical analyses.

This funding opportunity seeks applications addressing three of PCORI’s National Priorities for Health. To be considered responsive, applications must propose research that meets this PFA’S distinctive requirements and addresses at least one of the following National Priorities for Health:

  • Increase Evidence for Existing Interventions and Emerging Innovations in Health. Goal: Strengthen and expand ongoing comparative clinical effectiveness research focused on both existing interventions and emerging innovations to improve healthcare practice, health outcomes, and health equity.
  • Accelerate Progress Toward an Integrated Learning Health System. Goal: Foster actionable, timely, place-based, and transformative improvements in patient-centered experiences, care provision, and ultimately improved health outcomes through collaborative, multisectoral research to support a health system that understands and serves the needs and preferences of individuals.
  • Achieve Health Equity. Goal: Expand stakeholder engagement, research, and dissemination approaches that lead to continued progress toward achieving health equity in the United States.

Applicants will be asked to select one of these three National Priorities as primary, and if relevant, a secondary and/or tertiary National Priority in their Letter of Intent (LOI) and, if invited, a full application.

Program Requirements:

General Research Requirements:


Additional Eligibility Criteria
In general, applications for the conduct of research and management of funding may be submitted by appropriate academic research, private sector research, or study-conducting entities. This may include, among others, agencies and instrumentalities of the Federal Government, nonprofit and for-profit research organizations, and colleges and universities.

Per PCORI’s authorizing statute, every applicant must demonstrate capability to comply with the following conditions:
- Abide by the transparency and conflicts of interest requirements that apply to PCORI with respect to the research managed or conducted under contract;
- Comply with the PCORI methodological standards adopted by the Board of Governors;
- Consult, as appropriate, with the expert advisory panels for clinical trials and rare disease;
- Deposit de-identified data from the original research into a PCORI-designated repository to facilitate data sharing, as appropriate;
- Have appropriate processes in place to manage data privacy and meet ethical standards for the research;
- Comply with the requirements of PCORI for making the information available to the public; and
- Comply with other terms and conditions determined necessary by PCORI to carry out the research project.

Potential applicants are strongly encouraged to review the standard research contract prior to application.

Individuals are not permitted to apply.

Categories of Unresponsiveness:

Pre-Application Information
Key Dates:
- Online System Opens: May 2, 2023
- Applicant Town Hall: May 19, 2023; 11:30am - 1:00pm ET
- Letter of Intent Deadline: May 31, 2023; 5:00 pm ET
- Letter of Intent Status Notification: June 27, 2023
- Application Deadline: August 29, 2023; 5:00 pm ET
- Merit Review: November 2023
- Awards Announced: March 2024
- Earliest Start Date: July 2024

Applying for funding through this PFA is a two-stage process. An LOI must be submitted, and an applicant must be invited to submit an application. Only applicants whose LOIs are deemed most responsive to this PFA will be invited to submit a full application.

Applicant FAQs:


View recorded Applicant Town Hall:

Additional Funding Information

Estimated Total Program Funding:


Estimated Size of Grant
Maximum Project Budget: $22 million (Feasibility phase maximum: $2 million; Full-scale study phase: $20 million)

Term of Contract
Maximum Project Period: up to 6.5 years
- Feasibility Phase: 1.5 years
- Full-scale Study Phase: 5 years

The maximum Research Period of Performance does not include the Peer Review timeframe.

This PFA does not consider exceptions to the research period-of-performance limits. PCORI will not review submissions exceeding the stated research period of performance.

Contact Information
Apply online:

For programmatic inquiries, contact

Administrative, Financial, or Technical Inquiries:

Patient-CenteredOutcomes Research Institute
1333 New Hampshire Ave NW, Suite 1200
Washington, DC 20036
Phone: 202-827-7700
Fax: 202-355-9558

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