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Greater Value Portfolio Grant

Grants to USA Investigators for
Healthcare-Related Research

Agency Type:

Foundation / Corporation

Funding Source:

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Donaghue Foundation

LOI Date:


Deadline Date:



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Grants to USA investigators at tax-exempt research institutions for research related to healthcare. Applicants must submit an LOI prior to submitting a full application. Under this grant program, researchers will partner with healthcare service providers to test promising strategies that organizations can readily use to improve the value of the healthcare they provide to patients and communities.

In 2021, the Donaghue Foundation’s Greater Value Portfolio grant program will fund research projects for the purpose of advancing promising approaches to achieve a higher value healthcare system. Investigators conducting research to develop actionable solutions to one or more of these symptoms of low-value healthcare are encouraged to apply to the Greater Value Portfolio program:

  • High and rising healthcare costs
  • Unwarranted variation in prices,
  • Racial and ethnic disparities in access, prices and outcomes
  • Unaffordable cost of care burden on patients and families
  • Unacceptable variation in quality
  • Lack of transparency in both price and outcomes

Investigators conducting research to develop actionable solutions to one or more of these symptoms of low-value healthcare are encouraged to apply to the Greater Value Portfolio program.

Eligible topics include studies that focus on improving value through promising strategies using one or more of these approaches:

  • Test models of care, coverage or system change that  seek to improve value by addressing one or more of the symptoms of low value
  • Reduce treatments, tests, and screenings for patients for whom the potential harms (including financial harm) outweigh potential benefits
  • Provide tools to help consumers make decisions about their healthcare based on value, including the cost of care to patients, in addition to other patient-centered factors
  • Promote conversations between patients and their clinicians and care teams about preferences and trade-offs related to alternative treatment options and /or out of pocket cost burden to patients and families
  • Test interventions geared to increasing equity through the provision of higher value healthcare

For eligible uses of grant funds, see

GrantWatch ID#:

GrantWatch ID#: 155209

Number of Grants:

In 2021, the Foundation expects to make four awards.

Estimated Size of Grant:

The Trustees will commit up to $400,000 per award plus a 10% indirect rate to each selected investigator.

Term of Contract:

The duration of the award is two years. Grant term begins: January 2022. No-cost extensions may be requested.

Additional Eligibility Criteria:

This program is open to PhD (or equivalent) investigators at tax-exempt research institutions in the United States. In order to receive an award, the applicant must partner with an organization that delivers healthcare services or be a researcher based in a research unit embedded in a healthcare organization. Partner organizations cannot be the applicant organization.

Applicant organization must be 501(c)3 research institutions. Donaghue requires that the applicant organization has adequate infrastructure to assure:
- Ethical conduct of research, protection of research participants, and appropriate data protections
- Financial monitoring of grant awards and administering any related subcontracts
- Resources to assist the principal investigator with dissemination activities

Topics that are not considered relevant to the purpose of the program are efficacy trials, basic research, or research using animal models.

For ineligible uses of grant funds, see

Pre-Application Information:

Timeline for Application Process
- April 26, 2021: Letters of intent due by 5:00pm EST
- June 4, 2021: Notice of LOI decision
- July 30, 2021: Applications due
- January 2022: Grant term begins

The application process has two phases. Phase 1 is a letter of intent. Following a review of all letters of intent, the Foundation will begin Phase 2 by inviting some applicants to complete a more substantial application.

Information Session (video):

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

LOI forms and applications must be submitted electronically to Stacy Cloud at

You are invited to contact the Foundation with questions about eligibility, suitable research topics, or other questions about the Greater Value Portfolio program by emailing Stacy Cloud at the email address above.

The Patrick and Catherine Weldon Donaghue Medical Research Foundation
18 North Main Street
West Hartford, Connecticut 06107-1998

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

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